Whenever it becomes known how good he is with guns, ex-gunman George and his wife Dora have to flee the town, in fear of all the gunmen who might want to challenge him. Unfortunately he again spills his secret when he's drunk. All citizens swear to keep his secret and support him to give up his guns forever -- but a boy tells the story to a gang of wanted criminals. Their leader threatens to burn down the whole town, if he doesn't duel him.

Schoolteacher and family man Ed Avery, who's been suffering bouts of severe pain and even blackouts, is hospitalized with what's diagnosed as a rare inflammation of the arteries. Told by doctors that he probably has only months to live, Ed agrees to an experimental treatment: doses of the hormone cortisone. Ed makes a remarkable recovery, and returns home to his wife, Lou, and their son, Richie. He must keep taking cortisone tablets regularly to prevent a recurrence of his illness. But the "miracle" cure turns into its own nightmare as Ed starts to abuse the tablets, causing him to experience increasingly wild mood swings.